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Tutte le informazioni presenti su questo sito sono di origine pubblica e ne e' incoraggiata la diffusione. In nessun caso sono state violate norme di sicurezza o segreti militari.
  Uranio impoverito
Documenti

Nell'agosto del 1998 e' stato pubblicato questo articolo su Environmental Health Perspectives che mostra come l'uranio impoverito sia in grado di provocare la formazione di cellule cancerogene

Transformation of Human Osteoblast Cells to the Tumorigenic Phenotype by Depleted Uranium-Uranyl Chloride
Alexandra C. Miller, William F. Blakely, David Livengood, Tim Whittaker, Jiaquan Xu, John W. Ejnik, Matthew M. Hamilton, Eric Parlette, Theodore St. John, Henry M. Gerstenberg, and Hannah Hsu
Applied Cellular Radiobiology Department and Radiation Sciences Department, Armed Forces Radiobiology Research Institute, Bethesda, USA
Molecular Pharmacology Branch, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, USA

Abstract
Depleted uranium (DU) is a dense heavy metal used primarily in military applications. Although the health effects of occupational uranium exposure are well known, limited data exist regarding the long-term health effects of internalized DU in humans. We established an in vitro cellular model to study DU exposure. Microdosimetric assessment, determined using a Monte Carlo computer simulation based on measured intracellular and extracellular uranium levels, showed that few (0.0014%) cell nuclei were hit by alpha particles. We report the ability of DU-uranyl chloride to transform immortalized human osteoblastic cells (HOS) to the tumorigenic phenotype. DU-uranyl chloride-transformants are characterized by anchorage-independent growth, tumor formation in nude mice, expression of high levels of the k-ras oncogene, reduced production of the Rb tumor-suppressor protein, and elevated levels of sister chromatid exchanges per cell. DU-uranyl chloride treatment resulted in a 9.6 ( 2.8)-fold increase in transformation frequency compared to untreated cells. In comparison, nickel sulfate resulted in a 7.1 ( 2.1)-fold increase in transformation frequency. This is the first report showing that a DU compound caused human cell transformation to the neoplastic phenotype. Although additional studies are needed to determine if protracted DU exposure produces tumors in vivo, the implication from these in vitro results is that the risk of cancer induction from internalized DU exposure may be comparable to other biologically reactive and carcinogenic heavy-metal compounds (e.g., nickel). Key words: alpha radiation, depleted uranium, osteoblast, transformation. Environ Health Perspect 106:465-471 (1998). [Online 6 July 1998]